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  • CAS No.: 10592-13-9
  • Other Names: doryx;spanor
  • MF: C22H24N2O8
  • EINECS No.: 209-271-1
  • Place of Origin: China (Mainland)
  • Type: Auxiliaries and Other Medicinal Chemicals
  • Grade Standard: Medicine Grade
  • Usage: Animal Pharmaceuticals
  • Brand Name: Novachem
  • usage: Antibacterial

Packaging & Delivery

Packaging Details 25kg/drum
Delivery Time within 15days after receiving the payment

Product Details:

CAS No:10592-13-9
Molecular Weight:480.9 g/mol
Chemical Formula:C22H25ClN2O8
Assay/Purity:Typically NLT 98%
IUPAC Name:(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione hydrochloride

Doxycycline Hydrochloride News:

Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. Doxycycline is a semisynthetic tetracycline invented and clinically developed in the early 1960s by Pfizer Inc. and marketed under the brand name Vibramycin. Vibramycin received U.S. Food and Drug Administration (FDA) approval in 1967, becoming Pfizer's first once-a-day, broad-spectrum antibiotic. Other brand names include Monodox, Microdox, Periostat, Vibra-Tabs, Oracea, Doryx, Vibrox, Adoxa, Doxyhexal, Doxylin, Doxoral,Doxy-1 and Atridox (topical doxycycline hyclate for periodontitis).

 Indicated uses

As well as the general indications for all members of the tetracycline antibiotics group, doxycycline is frequently used to treat chronic prostatitis, sinusitis, syphilis, chlamydia, pelvic inflammatory disease,  acne, rosacea, and rickettsial infections.

Antiprotozoal

It is used in prophylaxis against malaria. It should not be used alone for initial treatment of malaria, even when the parasite is doxycycline-sensitive, because the antimalarial effect of doxycycline is delayed. This delay is related to its mechanism of action, which is to specifically impair the progeny of the apicoplast genes, resulting in their abnormal cell division.

It can be used in a treatment plan in combination with other agents, such as quinine.

Antibacterial

It is used in the treatment and prophylaxis of Bacillus anthracis (anthrax).

It is also effective against Yersinia pestis (the infectious agent of bubonic plague), and is prescribed for the treatment of Lyme disease, ehrlichiosis and Rocky Mountain spotted fever. In fact, because doxycycline is one of the few medications shown to be effective in treating Rocky Mountain spotted fever (with the next-best alternative being chloramphenicol), doxycycline is indicated even for use in children for this illness. Otherwise, doxycycline is not indicated for use in children under the age of eight years. Doxycycline, like other antibiotics, will not work for colds, influenza, or other viral infections.

When bacteriologic testing indicates appropriate susceptibility to the drug, doxycycline may be used to treat and prevent:

  • Escherichia coli
  • Chlamydia trachomatis
  • Enterobacter aerogenes (formerly Aerobacter aerogenes)
  • Lyme disease, aka Lyme borreliosis complex (B. burgdorferi)
  • Rocky mountain spotted fever
  • Folliculitis
  • Acne and other inflammatory skin diseases, such as hidradenitis suppurativa
  • Shigella species
  • Acinetobacter species (formerly Mima species and Herellea species)
  • Respiratory tract infections caused by Haemophilus influenzae
  • Respiratory tract and urinary tract infections
  • Upper respiratory infections caused by Streptococcus pneumoniae (formerly Diplococcus pneumoniae)
  • Methicillin-resistant Staphylococcus aureus (MRSA) infections

Anthelmintic

Elephantiasis is the end-stage condition of lymphatic filariases caused by one of two genera of filarial nematodes (roundworms): Wuchereria or Brugia (primarily Wuchereria bancrofti). Elephantiasis is characterized by permanently swollen limbs or genitals and permanent damage to the lymph system (often accompanied by severe secondary fungal and bacterial infections). This results from blockage of lymph flow caused by immune response against dead or dying adult worms in the lymphatics. This condition affects over 120 million people worldwide, with 1 billion at risk. Previous antinematode treatments have been limited by poor levels of effectiveness, drug side effects and high costs. Doxycycline was shown in 2003 to kill the symbiotic Wolbachia bacteria in the filarial worms' reproductive tracts, rendering them sterile, thus reducing transmission of the disease. Field trials in 2005 showed doxycycline almost completely eliminates the release of microfilariae when given for an 8 week course. However, doxycycline only reduces transmission and the relatively light pathology associated with microfilaraemia; there is currently no cure for lymphatic filariasis.

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